Publications
Lindsay M Reynolds, Rahul Dutta, Michael C Seeds, Kirsten N Lake, Brian Hallmark, Rasika A Mathias, Timothy D Howard, Floyd H Chilton
Scientific Reports, 2020
Susan Sergeant, Brian Hallmark, Rasika A Mathias, Tammy L Mustin, Priscilla Ivester, Maggie L Bohannon, Ingo Ruczinski, Laurel Johnstone, Michael C Seeds, Floyd H Chilton
American Journal of Clinical Nutrition, 2020
Evolution of Hominin Polyunsaturated Fatty Acid Metabolism: From Africa to the New World
Daniel N Harrris, Ingo Ruczinski, Lisa R Yanek, Lewis C Becker, Diane M Becker, Heinner Guio, Tao Cui, Floyd H Chilton, Rasika A Mathias, Timothy D O'Connor
Genome Biology and Evolution, 2019
Floyd H Chilton, Rahul Dutta, Lindsay M Reynolds, Susan Sergeant, Rasika A Mathias, Michael C Seeds
Nutrients, 2017
Floyd H Chilton, Robert C Murphy, Bryan A Wilson, Susan Sergeant, Hannah Ainsworth, Michael C Seeds, Rasika A Mathias
Nutrients, 2014
Genetic Variants in the FADS Gene: Implications for Dietary Recommendations for Fatty Acid Intake
Rasika A Mathias, Vrindarani Pani, Floyd H Chilton
Current Nutrition Reports, 2014
Austin G Hester, Robert C Murphy, Charis J Uhlson, Priscilla Ivester, Tammy C Lee, Susan Sergeant, Leslie R Miller, Timothy D Howard, Rasika A Mathias, Floyd H Chilton
Journal Biological Chemistry, 2014
Improving natural product research translation: from source to clinical trial
Barbara C Sorkin, Adam J Kuszak, Gregory Bloss, Naomi K Fukagawa, Freddie Ann Hoffman, Mahtab Jafari, Bruce Barrett, Paula N Brown, Frederic D Bushman, Steven J Casper, Floyd H Chilton, Chritopher S Coffey, Mario G Ferruzzi, D Craig Hopp, Mairead Kiely, Daniel Lakens, John B MacMillan, David O Meltzer, Marco Pahor, Jeffrey Paul, Kathleen Pritchett-Corning, Sara K Quinney, Barbara Rehermann, Kenneth D R Setchell, Nisha S Sipes, Jacqueline M Stephens, D Lansing Taylor, Herve Tiriac, Michael A Walters, Dan Xi, Giovanna Zappala, Guido F Pauli
The FASEB Journal, 2020
Genomics in Personalized Nutrition: Can You “Eat for Your Genes”?
Veronica A Mullins, William Bresette, Laurel Johnstone, Brian Hallmark, Floyd H Chilton
Nutrients, 2020
Beverly Dosso, Charlotte Mae K Waits, Kelli N Simms, Susan Sergeant, D Clark Files, Timothy D Howard, Carl D Langefeld, Floyd Hc Chilton, Elaheh Rahbar
Current Developments in Nutrition, 2020
Floyd H Chilton, Rahul Dutta, Lindsay M Reynolds, Susan Sergeant, Rasika A Mathias, Michael C Seeds
Nutrients, 2017
Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes
Susan Sergeant, Elaheh Rahbar, Floyd H Chilton
European Journal of Pharmacology, 2016
Tammy C Lee, Priscilla Ivester, Austin G Hester, Susan Sergeant, Larry Douglas Case, Timothy Morgan, Ethel O Kouba, Floyd H Chilton
Lipids in Health and Disease, 2014
Leslie B Poole, Derek Parsonage, Susan Sergeant, Leslie R Miller, Jingyun Lee, Cristina M Furdui, Floyd H Chilton
Biotechnology for Biofuels, 2020
Mingxuan Wang, Haiqin Chen, Aisikaer Ailati, Wei Chen, Floyd H Chilton, W Todd Lowther, Yong Q Chen
Applied Microbiology and Biotechnology, 2017
Featured Publications
Journal of Clinical Investigations, 2021, 131(19):e149236
There is an urgent need to identify cellular/molecular mechanisms responsible for severe COVID-19 progressing to mortality. We performed untargeted/targeted lipidomics and focused biochemistry on 127 plasma samples and found elevated metabolites associated with secreted phospholipase A2 (sPLA2) activity and mitochondrial dysfunction in severe COVID-19 patients. Deceased COVID-19 patients had higher levels of circulating, catalytically active sPLA2 Group IIA (sPLA2-IIA), with a median value 9.6-fold higher than mild patients and 5.0-fold higher than severe COVID-19 survivors. Elevated sPLA2-IIA levels paralleled several indices of COVID-19 disease severity (e.g., kidney dysfunction, hypoxia, multiple organ dysfunction). A decision tree generated by machine learning identified sPLA2-IIA levels as a central node in stratifying patients that succumbed to COVID-19. Random forest analysis and LASSO-based regression analysis additionally identified sPLA2-IIA and blood urea nitrogen (BUN) as the key variables among 80 clinical indices in predicting COVID-19 mortality. The combined PLA-BUN index performed significantly better than either alone. An independent cohort (n=154) confirmed higher plasma sPLA2-IIA levels in deceased patients vs. severe or mild COVID-19, with the PLA-BUN index-based decision tree satisfactorily stratifying mild, severe, and deceased COVID-19 patients. With clinically tested inhibitors available, this study supports sPLA2-IIA as a therapeutic target to reduce COVID-19 mortality.
Nutrients 2020, 12(10), 3118
Science in the 20th century yielded a basic understanding of the key macro and micro nutritional requirements for most humans. This resulted in a one-size-fits-all approach to nutrition, which has been impactful in reducing malnutrition and diseases resulting from nutrient deficiencies. However, evolutionary studies reveal that humans adapted to their ancestral diets and local environments, which resulted in population- or region-specific genetic variation. Consequently, individuals in large modern populations with diverse genetic ancestries, such as the US, may have a wide range of metabolic responses to the same food or diet, calling into question the one-size-fits-all dietary approach. Precision nutrition (sometimes called personalized nutrition, nutrigenetics, or nutritional genetics) is an emerging field of science which explores the concept of diets tailored to an individual’s personal biology.