FADS genetic and metabolomic analyses identify the Δ5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids

Lindsay M Reynolds, Rahul Dutta, Michael C Seeds, Kirsten N Lake, Brian Hallmark, Rasika A Mathias, Timothy D Howard, Floyd H Chilton

Scientific Reports, 2020

Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid- and gamma-linolenic acid-containing botanical oils

Susan Sergeant, Brian Hallmark, Rasika A Mathias, Tammy L Mustin, Priscilla Ivester, Maggie L Bohannon, Ingo Ruczinski, Laurel Johnstone, Michael C Seeds, Floyd H Chilton

American Journal of Clinical Nutrition, 2020

Evolution of Hominin Polyunsaturated Fatty Acid Metabolism: From Africa to the New World

Daniel N Harrris, Ingo Ruczinski, Lisa R Yanek, Lewis C Becker, Diane M Becker, Heinner Guio, Tao Cui, Floyd H Chilton, Rasika A Mathias, Timothy D O'Connor

Genome Biology and Evolution, 2019

Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases

Floyd H Chilton, Rahul Dutta, Lindsay M Reynolds, Susan Sergeant, Rasika A Mathias, Michael C Seeds

Nutrients, 2017

Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases

Floyd H Chilton, Robert C Murphy, Bryan A Wilson, Susan Sergeant, Hannah Ainsworth, Michael C Seeds, Rasika A Mathias

Nutrients, 2014

Genetic Variants in the FADS Gene: Implications for Dietary Recommendations for Fatty Acid Intake

Rasika A Mathias, Vrindarani Pani, Floyd H Chilton

Current Nutrition Reports, 2014

Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans

Austin G Hester, Robert C Murphy, Charis J Uhlson, Priscilla Ivester, Tammy C Lee, Susan Sergeant, Leslie R Miller, Timothy D Howard, Rasika A Mathias, Floyd H Chilton

Journal Biological Chemistry, 2014

Improving natural product research translation: from source to clinical trial

Barbara C Sorkin, Adam J Kuszak, Gregory Bloss, Naomi K Fukagawa, Freddie Ann Hoffman, Mahtab Jafari, Bruce Barrett, Paula N Brown, Frederic D Bushman, Steven J Casper, Floyd H Chilton, Chritopher S Coffey, Mario G Ferruzzi, D Craig Hopp, Mairead Kiely, Daniel Lakens, John B MacMillan, David O Meltzer, Marco Pahor, Jeffrey Paul, Kathleen Pritchett-Corning, Sara K Quinney, Barbara Rehermann, Kenneth D R Setchell, Nisha S Sipes, Jacqueline M Stephens, D Lansing Taylor, Herve Tiriac, Michael A Walters, Dan Xi, Giovanna Zappala, Guido F Pauli

The FASEB Journal, 2020

Genomics in Personalized Nutrition: Can You “Eat for Your Genes”?

Veronica A Mullins, William Bresette, Laurel Johnstone, Brian Hallmark, Floyd H Chilton

Nutrients, 2020

Impact of rs174537 on Critically Ill Patients with Acute Lung Injury: A Secondary Analysis of the OMEGA Randomized Clinical Trial

Beverly Dosso, Charlotte Mae K Waits, Kelli N Simms, Susan Sergeant, D Clark Files, Timothy D Howard, Carl D Langefeld, Floyd Hc Chilton, Elaheh Rahbar

Current Developments in Nutrition, 2020

Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases

Floyd H Chilton, Rahul Dutta, Lindsay M Reynolds, Susan Sergeant, Rasika A Mathias, Michael C Seeds

Nutrients, 2017

Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes

Susan Sergeant, Elaheh Rahbar, Floyd H Chilton

European Journal of Pharmacology, 2016

The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population

Tammy C Lee, Priscilla Ivester, Austin G Hester, Susan Sergeant, Larry Douglas Case, Timothy Morgan, Ethel O Kouba, Floyd H Chilton

Lipids in Health and Disease, 2014

Acyl-lipid desaturases and Vipp1 cooperate in cyanobacteria to produce novel omega-3 PUFA-containing glycolipids 

Leslie B Poole, Derek Parsonage, Susan Sergeant, Leslie R Miller, Jingyun Lee, Cristina M Furdui, Floyd H Chilton

Biotechnology for Biofuels, 2020

Substrate specificity and membrane topologies of the iron-containing ω3 and ω6 desaturases from Mortierella alpine 

Mingxuan Wang, Haiqin Chen, Aisikaer Ailati, Wei Chen, Floyd H Chilton, W Todd Lowther, Yong Q Chen

Applied Microbiology and Biotechnology, 2017

Featured Publications


Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality

Journal of Clinical Investigations, 2021, 131(19):e149236

There is an urgent need to identify cellular/molecular mechanisms responsible for severe COVID-19 progressing to mortality. We performed untargeted/targeted lipidomics and focused biochemistry on 127 plasma samples and found elevated metabolites associated with secreted phospholipase A2 (sPLA2) activity and mitochondrial dysfunction in severe COVID-19 patients. Deceased COVID-19 patients had higher levels of circulating, catalytically active sPLA2 Group IIA (sPLA2-IIA), with a median value 9.6-fold higher than mild patients and 5.0-fold higher than severe COVID-19 survivors. Elevated sPLA2-IIA levels paralleled several indices of COVID-19 disease severity (e.g., kidney dysfunction, hypoxia, multiple organ dysfunction). A decision tree generated by machine learning identified sPLA2-IIA levels as a central node in stratifying patients that succumbed to COVID-19. Random forest analysis and LASSO-based regression analysis additionally identified sPLA2-IIA and blood urea nitrogen (BUN) as the key variables among 80 clinical indices in predicting COVID-19 mortality. The combined PLA-BUN index performed significantly better than either alone. An independent cohort (n=154) confirmed higher plasma sPLA2-IIA levels in deceased patients vs. severe or mild COVID-19, with the PLA-BUN index-based decision tree satisfactorily stratifying mild, severe, and deceased COVID-19 patients. With clinically tested inhibitors available, this study supports sPLA2-IIA as a therapeutic target to reduce COVID-19 mortality.

DNA Strands

Genomics in Personalized Nutrition: Can You "Eat for Your Genes"?

Nutrients 2020, 12(10), 3118

Science in the 20th century yielded a basic understanding of the key macro and micro nutritional requirements for most humans. This resulted in a one-size-fits-all approach to nutrition, which has been impactful in reducing malnutrition and diseases resulting from nutrient deficiencies. However, evolutionary studies reveal that humans adapted to their ancestral diets and local environments, which resulted in population- or region-specific genetic variation.  Consequently, individuals in large modern populations with diverse genetic ancestries, such as the US, may have a wide range of metabolic responses to the same food or diet, calling into question the one-size-fits-all dietary approach. Precision nutrition (sometimes called personalized nutrition, nutrigenetics, or nutritional genetics) is an emerging field of science which explores the concept of diets tailored to an individual’s personal biology.